The Criticisms of Scalon's Millan Principle Essay

The Criticisms of Scalon's Millan Principle - Essay Example The Millian principle on Liberty simply means that certain harms may have had no probability of occurring if, not for some expressed actions. However, once these harms occur, the perpetrators may not justify their actions by legally restricting the actions. These harms include; those that originate from certain acts of expression, which include deceiving the individuals into having false beliefs and acts of expressions, which lead people into acting in ways that may lead to harmful consequences, especially in situations where there is a correlation between the act of expression and the succeeding harmful consequences. This correlation simply includes a mere fact that the act of expression facilitated the agents’ belief or led them to believe that it would be worthy performing the acts. Scanlon defended this principle by illustrating that it was a consequence of a certain idea regarding limits of justifiable political authority. That the government’s legitimate powers ar e restricted to people that can be protected on incompatibility grounds, with the citizen’s authority Scanlon (1979, p. 529). However, Scanlon does not fully agree with this principle. In his criticism, Scanlon argues that the Millian principle aimed at ruling out censorship arguments to which Mill was responding. The principle did this by declaring that the harmful consequences appealed by this argument cannot count as prospective justification for lawful restrictions of expression. However, Scanlon argues that there are supplementary ways of arriving at policies that would seem incompatible with freedom of expression. Freedom of expression refers to the participant’s right not to be prohibited from expressing themselves Bosmajian (1988 p. 122). Scanlon argues that the principle obtains what seems to be an implausible consequence in certain instances. He says that it would be difficult to see how this principle squares laws against misleading advertising on television . In this respect, Scanlon articulates that probably the regulation policies violate the freedom of expression Scanlon (1979, p.534). However, if the policies are acceptable, then they could be paradigms of paternalism. In Scanlon’s view, if anyone could take the first clause of the Millian principle as a restriction set aside in instances where rational capacities are rigorously diminished, it would constitute a dismissal of paternalism. An adequate justification doctrine of paternalism must consider certain factors such as the value associated with the ability for an individual to make their own decisions, the costs of making these decisions and the risks associated with empowering the government to make decisions on people’s behalf. These factors are unique to every case, and may be applicable even in cases where there is no common loss of rational capabilities. However, Scanlon argues that the problems associated with the Millian principle are not only limited to j ustification of paternalism. The principle also protects the interests of important audiences. These interests include the interest of choosing their beliefs and reasons to act on their beliefs. These interests rely not only on the freedom of expression, but also on means of accessing information, education and other issues critical to decision making. Sometimes, supplementary information is

Dopamine transporter phosphorylation site threonine 53 regulates Research Paper

Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux - Research Paper Example (29702). Activities that lead to the reuptake of DAT are crucial for the functionality of the dopaminergic neurons. Dopaminergic disorders, for instance, schizophrenia and depression among others may come about as a result of dysregulation of the transport of DAT, which causes an inequality of dopamine. Commonly abused substances including drugs such as cocaine and amphetamine are often targeted by DAT. In addition, therapeutic agents that treat dopamine complications are also targeted by DAT. Specifically, AMPH and its congeners induce multiple short-term and long-term effects on DAT. The mechanism behind the efflux is related with transporter-generated currents. Various techniques have been used to determine the precise phosphorylation site of DAT. It has been established that that a recombinant peptide containing N-terminal residues 1–65 of rDAT underwent phosphorylation outside living tissues in the presence of proline-guided kinases. It was also established that the precise phosphorylation site in heterologously expressed protein was a threonine residue, which was located at position 53. However, it was vital to ascertain the phosphorylation site using other techniques. The researchers in this paper aimed at determining the role of dopamine transporter phosphorylation site threonine 53 on the reabsorption of the substrate and amphetamine-triggered efflux Foster et al. (29702). The researchers make use of mass spectrometry and a novel antibody that is specific to phosphates to ascertain the presence of DAT phosphorylation at Thr53 in striatal tissue obtained from rodents as well as heterologous expression systems. Cell culture and dopamine transporter mutagenesis was done using Lewis carcinoma cells that were stably expressing WTrDAT (rDAT-LLCPK) (31) or T53A or T53D rDAT and were maintained in alpha minimum essential medium. Dulbeccos modified